In vitro antischistosomal evaluation of some newly synthesized praziquantel derivatives

Autor:	Mohsen M. Kamel, Abdel-mohsen M. Soliman, Manal M. Anwar, Hala F. Abdelhamid
Rok vydání:	2012
Předmět:	Drug biology Chemistry media_common.quotation_subject General Chemistry Pharmacology biology.organism_classification In vitro Praziquantel medicine Schistosoma mansoni worm Schistosoma mansoni medicine.drug media_common
Zdroj:	Research on Chemical Intermediates. 39:3417-3426
ISSN:	1568-5675 0922-6168
DOI:	10.1007/s11164-012-0854-9
Popis:	Praziquantel, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, was used as the parent starting material to synthesize a new series of praziquantel-3-arylidene derivatives 1a–c and praziquantel–Mannich bases 2a–d, hoping to obtain new antischistosomal compounds of more activity and lower adverse effects. The antischistosomal activity of the newly synthesized compounds was evaluated using in vitro Schistosoma mansoni worm killing tests. Both compounds 2c and 2d exhibited significant in vitro antischistosomal activity and may offer promising use as an antischistosomal drug either alone or in combination with praziquantel.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::91625fb4fb433457f37358ae7f703286 https://doi.org/10.1007/s11164-012-0854-9 Zobrazit plný text záznamu Full text from SpringerLink