Metal Complexes of Biologically Important Ligands, XCl. Introduction of Organometallic Fragments into α-Amino Acids by Reactions of α-Bromoglycine Derivatives with Anionic Organotransition-Metal Compounds

Autor:	Wolfgang Steglich, Kurt Polborn, Bernd Kayser, Wolfgang Beck
Rok vydání:	1997
Předmět:	chemistry.chemical_classification chemistry.chemical_element Tungsten Medicinal chemistry Amino acid Inorganic Chemistry Metal Chromium chemistry.chemical_compound chemistry visual_art Side chain visual_art.visual_art_medium Organic chemistry Acetylferrocene
Zdroj:	Chemische Berichte. 130:171-177
ISSN:	1099-0682 0009-2940
Popis:	The reactions of protected α-bromoglycine esters R1(O)CNHCH(Br)CO2R2 (R1Ph, OCMe3; R2 Me, tBu) with organometallic anions of acetylferrocene, CpFe(CO)(PPh3)-C(O)CH3, (OC)5MC(OMe)CH3 (MCr, W), (OC)3Cr(η6-diphenylmethane), (OC)3Cr[η6-fluorene), (OC)3Cr(η6-dihydroanthracene) and of (OC)3Cr(-η6aniline) and (OC)3Cr(η6-o-toluidine) provide a method for the introduction of organometallic fragments into the side chains of α-amino acids.The complexes may be useful as markers for α-amino acids in peptides.The compound (OC))3Cr(η-o-C6H4(CH3)NHC-(H)(CO2Me)NHC(O)Ph was characterized by X-ray diffraction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::915eb51139338874c8bd35a919c99817 https://doi.org/10.1002/cber.19971300206 Zobrazit plný text záznamu Plný text