Olfactory sensory evaluation in newborn children of women infected with COVID-19 during pregnancy
| Autor: | Geraldo Magela Fernandes, José Alfredo Lacerda de Jesus, Thomas Lachmann, Kassandra Silva Falcão Costa, Jan Spilski, Karina Nascimento Costa, Rosana Maria Tristão, Laiane Medeiros Ribeiro |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Human Growth and Development. 31:192-198 |
| ISSN: | 2175-3598 0104-1282 |
| DOI: | 10.36311/jhgd.v31.11341 |
| Popis: | Introduction: In adults, olfactory loss is one of the earliest and most frequent acute clinical manifestations of SARS-CoV-2 infection. The number of children infected with SARS-CoV-2 is relatively small, perhaps due to the lower expression of Angiotensin Converting Enzyme 2 (ACE2) in children compared to adults. Little is known about foetal impairment in mothers infected with SARS-CoV-2. This paper describes an ongoing scientific project on smell perception in infants. Objective: The goal of the study is to develop and validate a behavioural evaluative scale of olfactory perception in healthy newborns and to apply this scale to newborn children of women infected with COVID-19 during pregnancy comparing to newborn children of women without COVID-19 infection history, in order to compare these groups. Methods: This is a retrospective comparative analytical cohort study of 300 newborns exposed and unexposed to COVID-19 during pregnancy. The data collection will follow the experimental procedure in a previous study that explored odours of the maternal breastmilk, vanilla (sweet) and distilled water (neutral). A coffee smell was implemented as an addition to this previous study in order to include acid/bitterness category to the categories of stimuli. Discussion: It is feasible to argue the hypothesis of the involvement of the foetus' olfactory bulb as one of the indelible pathophysiological manifestations to the clinical diagnosis of COVID-19 with neurosensory olfactory deficit in foetuses and newborns affected by intrauterine infection. This study aims to investigate if newborn children of women infected with COVID-19 during pregnancy have olfactory sensory changes. The clinical trial was registered in the Brazilian Registry of Clinical Trials (ReBEC- RBR-65qxs2). © 2021 The authors. All Rights Reserved. |
| Databáze: | OpenAIRE |
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