Cisplatin and 5-fluorouracil in the primary management of squamous esophageal cancer
| Autor: | Tat-Kin Tsang, Philip A. Schneider, Merrill S. Kies, Steven T. Rosen, Carl B. Wallemark, Ramananda M. Shetty, Thomas W. Shields |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Induction chemotherapy Esophageal cancer medicine.disease Surgery medicine.anatomical_structure Fluorouracil Esophagectomy Internal medicine Mucositis medicine Combined Modality Therapy Esophagus business medicine.drug |
| Zdroj: | Cancer. 60:2156-2160 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19871101)60:9<2156::aid-cncr2820600906>3.0.co;2-g |
| Popis: | A combined treatment program consisting of chemotherapy with cisplatin and infusion 5-fluorouracil (5-FU) for three cycles followed by esophagectomy or radiation, or both, has been conducted in 26 patients with squamous cancer of the esophagus localized to the primary site. Eleven patients had objective evidence of partial or complete response to the chemotherapy. Fourteen patients were operated on and ten underwent total esophagectomy. Drug toxicity was considerable with severe mucositis and myelosuppression occurring in 11 and seven patients, respectively. There were no drug-related deaths. Median survival is 17.8 months. Ten patients have lived more than 2 years. Six of these patients have undergone total thoracic esophagectomy after the induction chemotherapy. Determination of the ultimate benefits of combined modality therapy may require prospective randomized trials isolating the major treatment components but our data suggest that chemotherapy contributes to improved results in this disease and that drug therapy is emerging as an integral component of combined therapy. |
| Databáze: | OpenAIRE |
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