Neutrophil-lymphocyte ratio at diagnosis is an independent prognostic factor in patients with nodular sclerosis Hodgkin lymphoma: results of a large multicenter study involving 990 patients
| Autor: | Stefano Sacchi, Luigi Marcheselli, Luca Baldini, Aaron Polliack, Raffaella Marcheselli, Ariel Aviv, Massimo Federico, Sacchi Samantha Pozzi, Maria Christina Cox, Angela Ferrari, Tamar Tadmor, Giuseppe Pugliese, Paolo G. Gobbi, Alessia Bari |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research Pathology medicine.medical_specialty Multivariate analysis Lymphocyte Gastroenterology 03 medical and health sciences 0302 clinical medicine Nodular sclerosis Internal medicine medicine In patient Hematology business.industry fungi Hazard ratio General Medicine medicine.disease Lymphoma 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cohort business |
| Zdroj: | Hematological Oncology. 35:561-566 |
| ISSN: | 0278-0232 |
| Popis: | Several studies have demonstrated the prognostic value of neutrophil-lymphocyte ratio (NLR) in patients with solid tumors and non–Hodgkin lymphoma. In contrast, there is only sparse data on its prognostic role in patients with classical Hodgkin lymphoma (cHL). The aim of our study was to establish whether NLR could serve as an independent prognostic factor in a cohort of 990 patients with nodular sclerosis (NS)-cHL. After analysis of the log hazard ratio (HR) as a function of NLR, we chose the value 6 as cutoff. Patients with NLR >6 had a worse progression-free survival and overall survival compared to those with NLR ≤6; 84% vs 75% and 92% vs 88%, at 5 years, with an HR of 1.65 and 1.82, respectively. Multivariate analysis showed that the risk remained high with HR 1.44 and HR 1.54 in progression-free survival and overall survival, respectively. In summary, our study shows that NLR is a robust and independent prognostic parameter in NS-cHL, both in early and advanced disease. It is inexpensive and simple to apply. Thus, we conclude that NLR, possibly in combination with the international prognostic score and absolute monocyte count, is a useful guide for physicians treating NS-cHL patients. |
| Databáze: | OpenAIRE |
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