| Popis: |
The facts that human saliva, gathered aseptically, could split histamine and gastric hormone ‘production’ a hormone which FUJIE belives to be a histamine like substance, and that its mechanism of splitting seemed to be entirely enzymatic, were demonstrated by FUJIE and his colleagues (Arch. hist. jap. 6, 1954). The authors have recently perfomed experiments with parotin (OGATA) which has been recently produced by TEIKOKU ZOKI Co. Ltd. as a salivary gland preparation. The results obtained were as follows.1. Minute amount of parotin could split histamine and ‘productin (FUJIE)’ as saliva did or even stronger than that, regardless in vivo or in vitro. The authors used 1/10mg-1/500mg of parotin and the effects they showed were inversely proportional to the quantity of parotin.2. On the other hand, when 1-3mg of parotin were used, histamine increased remarkably both in vivo and in vitro, and the increasing of histamine was quite proportional to the amount of parotin. This does not coincide with the results in the foregoing paragraph. The authors do not know why it is so.However, it seems to be very important that the results of experiments with the minute amount parotin would coincide with those of the saliva experiments, for it is already known that parotin could be extracted from parotis glands of neats in 0.02-0.03% of the gland's weight. According to the results obtained previously on the saliva and those obtained here, the authors must admit OGATA's theory that saliva is absorbed from the striated duct into the blood. Saliva, which is absorbed into the blood, may play a great role in controling the histamine in the body and the gastric hormone ‘productin’, and the non-saliva disease (asialadenismus of OGATA) may occur under the condition of overaccumulating of ‘productin’ (histamine-like substance). |
