Sensitivity Analysis of the Electrocardiogram in Mouse Heart
| Autor: | Mauricio Castaño-Arcila, Alberto Ramírez-Hurtado, Humberto Montesinos Larrinaga, Jesús Rodríguez-González |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0209 industrial biotechnology
Physiological function Computer science 020208 electrical & electronic engineering 02 engineering and technology Venous blood Signal QRS complex 020901 industrial engineering & automation Control and Systems Engineering 0202 electrical engineering electronic engineering information engineering Sensitivity (control systems) Beat (music) Mouse Heart Biomedical engineering Parametric statistics |
| Zdroj: | IFAC-PapersOnLine. 53:16087-16091 |
| ISSN: | 2405-8963 |
| DOI: | 10.1016/j.ifacol.2020.12.427 |
| Popis: | The function of the heart is contracting and pump oxygenated blood to the body and deoxygenated blood to the lungs. To achieve this goal heart must beat regularly and continuously for entire life and respond to the changing requirements by the body. In this paper, we consider a mathematical model to produce ECG and analyze how the parametric variation can modify the electrocardiogram signal in the mouse heart. Numerical simulations were analyzed in detail, and compared with the control experiment, changes in frequency and ECG characteristics were evaluated. In agreement with physiological function, we find that the frequency of pacemaker cells can vary significantly, whereas electrical conducting cells maintain ECG characteristics in the face of parametric variations. P-wave, QRS complex, and T-wave can vary significantly in myocardial cells to parametric variations. |
| Databáze: | OpenAIRE |
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