Late Breaking Abstract - Holter ECG-based arrhythmia and heart rate analysis in patients with COPD receiving a fixed-dose combination of tiotropium/olodaterol versus its monocomponents
| Autor: | Ulrich Bothner, Matthias Trampisch, Alberto de la Hoz, Stefan Andreas, Peter Alter, Isabel Kloer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
COPD
medicine.medical_specialty Combination therapy business.industry Fixed-dose combination Olodaterol Cardiac arrhythmia medicine.disease 3. Good health chemistry.chemical_compound chemistry Internal medicine Heart rate cardiovascular system medicine Cardiology In patient cardiovascular diseases business Holter ecg |
| Zdroj: | Airway pharmacology and treatment. |
| Popis: | Introduction: Patients with COPD frequently exhibit cardiovascular comorbidities and are at risk of cardiac arrhythmias. To evaluate potential class effects of long-acting muscarinic antagonists and long-acting β2-agonists on an increased arrhythmia risk in COPD patients, further investigation is required. Aims: To analyse Holter ECG data from the TONADO 1+2 studies to assess the effect of tiotropium (5 µg) (Tio)/olodaterol (5 µg) (Olo) combination therapy (T/O) vs monocomponents on cardiac arrhythmia endpoints. Methods: Holter ECG monitoring was performed on a subset of patients (N=506) in two Phase III, replicate, multicentre studies at baseline and 12 weeks. Records were evaluated for 24-hour mean heart rate (HR), supraventricular premature beats (SVPBs) and ventricular premature beats (VPBs). Results: No pro-arrhythmic SVPB or VPB effect was observed for T/O vs Tio and Olo. The proportions of patients showing a decrease, increase or no change in SVPB and VPB from baseline was comparable across treatment groups (Figure). The change in mean HR from baseline to Week 12 was small and not clinically relevant in all treatment groups (-0.6 for T/O, 1.8 for Tio and 0.5 for Olo). Conclusions: Treatment with T/O combination therapy and its monocomponents is not associated with an increased rate of arrhythmias or heart rate as assessed by Holter ECG. |
| Databáze: | OpenAIRE |
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