ALTERNATE-DAY STEROID DOSING IMPROVES GROWTH WITHOUT ADVERSELY AFFECTING GRAFT SURVIVAL OR LONG-TERM GRAFT FUNCTION
| Autor: | William E. Harmon, E. K. Sullivan, E. D. Avner, Kathy Jabs |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Transplantation
Creatinine Kidney Chemotherapy medicine.medical_specialty Proportional hazards model medicine.drug_class business.industry medicine.medical_treatment Urology Surgery chemistry.chemical_compound surgical procedures operative medicine.anatomical_structure El Niño chemistry medicine Corticosteroid Dosing business |
| Zdroj: | Transplantation. 61:31-36 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-199601150-00008 |
| Popis: | Data from the North American Pediatric Renal Transplant Cooperative Study were analyzed to determine the effects of alternate-day (QOD) steroid dosing on growth, graft survival, and graft function in children with functioning grafts 12 months after transplantation. At 12 months after transplantation, 16.8% (337/2001) of transplant recipients were receiving QOD dosing. The basis for the selection of a steroid dosing regimen cannot be determined from registry data ; however, the frequency of QOD dosing differed by donor source, race, age at transplant, and the occurrence of rejection episodes in the first year. The effect of the steroid dosing pattern on growth was evaluated in children continuously on either QOD or daily (QD) steroid dosing. The mean change in the standardized height scores from 1 month to 24 months after transplantation was significantly greater in those on QOD dosing (+0.5±0.06) than in those on QD dosing (+0.1±0.03). Using multiple regression analyses, better growth was associated with QOD dosing, recipient age less than 13 years, lower total steroid dose over 48 hr, and lower serum creatinine (all P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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