Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT
| Autor: | Karsten Krüger, Christian Pilat, A Hillebrecht, Frank-Christoph Mooren, Christine Scheibelhut, Achim Wagner, R.-H. Bödeker, Torsten Frech, Jörn Pons-Kühnemann |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Area under the curve VO2 max Physical Therapy Sports Therapy and Rehabilitation Inflammation Placebo Gastroenterology medicine.anatomical_structure Cytokine Immune system Internal medicine White blood cell Immunology medicine Orthopedics and Sports Medicine Leukocytosis medicine.symptom business |
| Zdroj: | Scandinavian Journal of Medicine & Science in Sports. 25:534-542 |
| ISSN: | 0905-7188 |
| DOI: | 10.1111/sms.12265 |
| Popis: | Traumeel (Tr14) is a natural, combination drug, which has been shown to modulate inflammation at the cytokine level. This study aimed to investigate potential effects of Tr14 on the exercise-induced immune response. In a double-blind, randomized, controlled trial, healthy, untrained male subjects received either Tr14 (n = 40) or placebo (n = 40) for 24 h after a strenuous experimental exercise trial on a bicycle (60 min at 80%VO2 max). A range of antigen-stimulated cytokines (in vitro), white blood cell count, lymphocyte activation and apoptosis markers, and indicators of muscle damage were assessed up to 24 h following exercise. The area under the curve with respect to the increase (AUCI ) was compared between both groups. The Tr14 group showed a reduced exercise-induced leukocytosis and neutrocytosis (P |
| Databáze: | OpenAIRE |
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