| Autor: |
I. Martínez Cordellat, I Cánovas Olmos, JA Román Ivorra, C. Alcañiz Escandell, E. Labrador Sánchez, F.M. Ortiz Sanjuan, E. Grau Garcia, J. Ivorra Cortés, R. Negueroles Albuixech, R. Gonzalez Mazario, C. Feced Olmos, M. De la Rubia Navarro, JJ Fragio Gil, I. Chalmeta Verdejo, K. Arévalo Ruales, C. Nájera Herranz, JE Oller Rodriguez, E. Vicens Bernabeu, L. González Puig |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Scleroderma, myositis and related syndromes. |
| DOI: |
10.1136/annrheumdis-2018-eular.6318 |
| Popis: |
Background Raynaud’s phenomenon (RP) is frequently associated with the presence of scleroderma or other connective tissue diseases (CTD). Identify the presence of secondary RP is important to perform an adequate therapeutic management and to achieve the early control of these patients. Nailfold capillaroscopy is safe, economic, and relatively easy to perform and has proven to be useful in identifying patients with secondary RP. Objectives To assess a long-term follow-up primary RP patient’s series. Methods Retrospective observational study of a wide and unselected series of patients diagnosed as primary RP from a single university hospital from January 2012 to August 2017. Patients were classified as primary RP after the presence of CTD at the onset was excluded. Results We studied 214 patients (85.98% were female), with a mean age of 47.6±16.7 years (range 15–88). After a mean follow-up period of 46.4±23.3 months, 8 patients were diagnosed of a CTD (2 Scleroderma/Systemic sclerosis, 3 Systemic Lupus Erythematosus, 1 Rheumatoid arthritis and 2 Sjogren’s syndrome). The remaining 206 patients continued classified as primary RP. The main capillaroscopic patterns observed were: Normal (n=157), unspecific (n=49), scleroderma pattern (n=2) and suggestive of other rheumatic diseases pattern (n=6). All patients who developed a CTD during the follow-up, showed changes in successive nailfold capillaroscopic examinations. 20 of 206 patients who remained primary RP showed minor changes at successive nailfold capillaroscopy. The main capillaroscopic changes detected on this group were: presence of capillary tortuosity (n=4), presence of a decreased capillary density2 and the presence of capillary bleeding (n=16). Antinuclear antibodies (ANA) were positive at the onset in 34 patients and after follow-up in 39 patients. Conclusions After a mean follow-up period next to four years, most of our primary RP patients remained free of CTD. A minority of our patients showed changes at nailfold capillaroscopy exam or positivity of ANA. Disclosure of Interest None declared |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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