Continuous Drug Delivery with Levodopa/Carbidopa Infusion: Review and First Data of a Dutch Cohort

Autor:	Teus van Laar, Ad Hovestadt
Rok vydání:	2008
Předmět:	Psychiatry and Mental health business.industry Anesthesia Cohort Drug delivery Levodopa carbidopa Medicine Neurology (clinical) business nervous system diseases
Zdroj:	CNS Spectrums. 13:11-14
ISSN:	2165-6509 1092-8529
Popis:	A duodenal levodopa (L-dopa) and carbidopa infusion has been developed to stabilize plasma levels of L-dopa, in order to reduce existing motor response fluctuations. Stable plasma levels have been shown to reduce these fluctuations significantly. A constant duodenal infusion with an L-dopa solution can improve response fluctuations, however L-dopa has very poor solubility. Only in an acidic environment can L-dopa be dissolved in large volumes. To supply 1 day of infusion with the conventional L-dopa solution, ∼4–5 liters are necessary, an inconvenience to most patients. With L-dopa/carbidopa infusion, L-dopa and carbidopa are concentrated in a water-based gel-like suspension to 20 mg/mL, which has reduced the infusion volumes to
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9108d37d4b5aabfc03081498e241cc50 https://doi.org/10.1017/s1092852900017363 Zobrazit plný text záznamu