The stability of 1-cyclopropylmethyl-5(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (KB-509) in aqueous solution

Autor:	Sugimoto Isao, Awata Norio, Akimoto Koichi, Fujiwara Shigeru
Rok vydání:	1979
Předmět:	Hydrolysis chemistry.chemical_compound Aqueous solution chemistry Glycine Benzophenone Pharmaceutical Science Organic chemistry Ring (chemistry) Medicinal chemistry Derivative (chemistry)
Zdroj:	International Journal of Pharmaceutics. 3:109-115
ISSN:	0378-5173
DOI:	10.1016/0378-5173(79)90072-3
Popis:	The main degradation of 1-cyclopropylmethyl-5-(o-fluorophenyl)-7-chloro-l,3-dihydro-2H-1,4-benzodiazepin-2-one (KB-509) in aqueous solution involves a two-step consecutive mechanism. The first step is the hydrolysis of KB-509, yielding 5-chloro-cyclopropyl-methylamino-2'-fluorobenzophenone (1) and glycine. The second step is the ring closure of the benzophenone derivative to give 2-chloro-10-cyclopropylmethyl-9-acridanone (2) at all pH regions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9107055e2273b02a8d4e84527f4eb104 https://doi.org/10.1016/0378-5173(79)90072-3 Zobrazit plný text záznamu