Cohort KBP-2000-CPHG: Evaluation of prognosis factors for survival in primary bronchial cancer (PBC)
| Autor: | Jean-Luc Breton, François Blanchon, B. Duvert, M. Carlier, Mahmoud Zureik, Bernard Asselain, Marie-Claude Level, Michel Grivaux, G. Berthiot, A. Legroumellec |
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| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Journal of Clinical Oncology. 24:7204-7204 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | 7204 Background: PBC has a guarded prognosis despite advances in treatment. The main epidemiologic changes observed during the last fifteen years are the strong progression in its incidence in women and the increase in adenocarcinomas. A prospective study of overall survival and survival according to sex and prognosis factors was set up from the cohort of study KBP-2000-CPHG. Methods: KBP-2000-CPHG is a prospective epidemiological study conducted throughout the year 2000 on histologically confirmed PBC patients treated in general hospitals. 5,667 patients were included. A survival study based on patient outcomes was launched between September 2004 and March 2005 in 137 centres. Each centre had to provide information on the vital status of its patients with, in the event of death, the date and cause. In the absence of vital status data, a graduated tracing strategy was set up including the interrogation of various files: city hall of the place of birth,etc. Results: 135 investigator centres out of the 137 initial centres took part. The 2 non-participating centres represented 56 patients. The vital status could be defined for 5441 of the other 5611 patients (97.0%). 88.4% of these patients had died (average time between inclusion and death: 10.5–10.7 months). In univariate study, survival status is linked with age (p < 0.0001), tobacco consumption (p < 0.0001), performance status (p < 0.0001), cancer type (small versus non small cell lung cancer-NSCLC: p < 0.0001) and for the NSCLC, with histological type (p < 0.0001) and TNM stage (p < 0.0001). According to multivariate analysis, survival status is related to age, performance status, cancer type and among the NSCLC, to age, sex, performance status, histological type and TNM stage. Conclusions: The survival study on PBC is the first one in France, including more than 5,400 patients. The first results show the prognosis role of age, sex, histological type, performance status and TNM stage. No significant financial relationships to disclose. |
| Databáze: | OpenAIRE |
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