Synthesis of two novel oxocyclam-binding technetium complexes containing an analogue of cocaine
| Autor: | F. Riche, F. Turpin, N. Neuquelman, Fadi Masri, Patrick Emond, E. Berthommier, Christian Loc'h, Philippe Auzeloux, Laurent Mauclaire, M. Vidal |
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| Rok vydání: | 2002 |
| Předmět: |
biology
010405 organic chemistry medicine.drug_class Stereochemistry Organic Chemistry Carboxamide Tropane Transporter 010402 general chemistry 01 natural sciences Biochemistry Chemical synthesis 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound chemistry Spect imaging Drug Discovery medicine Lactam biology.protein Moiety Radiology Nuclear Medicine and imaging Spectroscopy Dopamine transporter |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 45:379-393 |
| ISSN: | 0362-4803 |
| Popis: | In order to visualize and quantify dopamine transporters, the synthesis of two novel ligands labelled with technetium-99 m (99mTc) has been investigated. A multi-step synthesis afforded two target ligands with a tropane skeleton and a macrocyclic complexing moiety. The choice and the position of substituents are in adequation with dopamine transporter structure. The radiolabelling of these ligands with 99mTc has been studied and the results make them good candidates for SPECT imaging. Copyright © 2002 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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