Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target
| Autor: | Chamodi K. Gardhi, Tatiana P. Soares da Costa, Matthew A. Perugini, Belinda M. Abbott, Rebecca M. Christoff |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Dihydrodipicolinate synthase Organic Chemistry Pharmaceutical Science Computational biology Biology Biochemistry Diaminopimelate decarboxylase Multiple drug resistance Diaminopimelate pathway Enzyme Antibiotic resistance chemistry Drug Discovery biology.protein Molecular Medicine |
| Zdroj: | MedChemComm. 10:1581-1588 |
| ISSN: | 2040-2511 2040-2503 |
| DOI: | 10.1039/c9md00107g |
| Popis: | Antibiotic resistance is only set to increase if significant action is not taken to combat the imminent threat of multidrug resistant pathogens. The development of inhibitors of the enzyme dihydrodipicolinate synthase (DHDPS), which is involved in the diaminopimelate pathway, represents an attractive approach to the discovery of new antibacterial agents. Herein, the challenges and opportunities of DHDPS inhibitors are discussed. |
| Databáze: | OpenAIRE |
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