| Popis: |
For the first time, the genetic background, which plays a crucial role in the susceptibility of this disease, has been studied in details in Iraq. The major role of the genetic background is supported by the increased occurrence of BD among relatives. There was markedly increased frequency of B51(5), DR2, DQ3 in both sporadic and familial cases of BD. It is of interest in this population study, that the haplotype, which may play crucial role in the susceptibility of BD is A9-B51(5)-CW1-DR2-DQ3, whereas A2, A28, B35, DR12, DQ4 phenotypes decrease the risk of developing BD. HLA DR1 and DQ1 could be considered genetic markers for aetiopathogenesis of the patient control group (ROU). |
