Prospective echocardiographic evaluation of patients with endogenous subclinical hyperthyroidism and after restoring euthyroidism
| Autor: | Dariusz Michałkiewicz, Marek Ruchała, Zbigniew Podgajny, Grzegorz Kamiński, Ewelina Szczepanek, Karol Makowski, Norbert Szalus, Grzegorz Gielerak |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Aorta education.field_of_study business.industry Endocrinology Diabetes and Metabolism Population Heart.chambers Left ventricular mass Endocrinology medicine.anatomical_structure Ventricle Internal medicine medicine.artery Thyroid hormones medicine education business Isovolumetric contraction Subclinical infection |
| Zdroj: | Clinical Endocrinology. 74:501-507 |
| ISSN: | 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2010.03957.x |
| Popis: | GrzegorzKaminski*,DariuszMichalkiewicz†,KarolMakowski†,ZbigniewPodgajny*,NorbertSzalus‡,MarekRuchala§,EwelinaSzczepanek§andGrzegorzGielerak†*DepartmentsofEndocrinologyandIsotopeTherapy,†InternalMedicineandCardiology,‡NuclearMedicine,MilitaryInstituteofMedicine,Warsawand§DepartmentofEndocrinology,MetabolismandInternalMedicine,PoznanUniversityofMedicalSciences,Poznan,PolandSummaryObjectivesClinical significance of, and the need for, treatment insubclinical hyperthyroidism (sHT) is still a matter of debate. Theaim of the study was to assess the impact of sHT on echocardio-graphic parameters.Design Patients with endogenous sHT of nonautoimmune originunderwent full echocardiographic assessment at diagnosis and afterrestoring euthyroidism with radioiodine treatment.Patients Studied group consisted of 44 patients (37 women, 7men), aged 22–65 years (mean 45AE9±11 AE0).Measurements Full echocardiographic assessment included esti-mation of cardiac chamber diameters and volume as well as cardiaccontractility, according to the guidelines of the American Society ofEchocardiography. Left ventricular mass was calculated accordingto Penn’s convention. For estimation of left ventricle diastolicfunction, the following echocardiographic parameters wereobtained: maximal early filling wave velocity (E), maximal late fill-ing wave velocity (A), E/A ratio, isovolumetric relaxation time andearly filling wave deceleration time.Results In the studied group, phase of sHT was associated withincreased volume of heart chambers, increased diameter of ascend-ing aorta, increased left ventricle mass and disturbed left ventriclerelaxation (P |
| Databáze: | OpenAIRE |
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