Targeting PAR2 with Pepducins
| Autor: | Ethan A. Lerner, Melissa S. Lee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification G protein Peptide Inflammation Cell Biology Dermatology Atopic dermatitis medicine.disease Biochemistry body regions Coupling (electronics) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Immunology otorhinolaryngologic diseases medicine medicine.symptom Pepducin skin and connective tissue diseases Receptor Molecular Biology |
| Zdroj: | Journal of Investigative Dermatology. 139:282-284 |
| ISSN: | 0022-202X |
| DOI: | 10.1016/j.jid.2018.09.008 |
| Popis: | Itch, inflammation, and atopic dermatitis are associated with activation of PAR2. Affecting PAR2 activity presents a number of challenges. Here, a cell-penetrating peptide, termed a pepducin, circumvents these challenges by preventing the receptor from coupling to G proteins. The pepducin modulates several models of itch, inflammation, and atopic dermatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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