Surface modified poly(methyl methacrylate) with 1-methyl- 2-methacrylamidoethyl phosphorylcholine moiety
| Autor: | Koji Ohga, Kazuo Sugiyama |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
food.ingredient Polymers and Plastics Chemistry Phosphorylcholine Organic Chemistry food and beverages Polymer Condensed Matter Physics Poly(methyl methacrylate) Lecithin chemistry.chemical_compound Adsorption food visual_art Polymer chemistry Materials Chemistry visual_art.visual_art_medium Moiety Physical and Theoretical Chemistry Methyl methacrylate Drug carrier |
| Zdroj: | Macromolecular Chemistry and Physics. 200:1439-1445 |
| ISSN: | 1521-3935 1022-1352 |
| Popis: | A series of poly(methyl methacrylate) [poly(MMA)] microspheres covered with the 1-methyl-2-methacrylamidoethyl phosphorylcholine (MAPC) moiety, poly(MAPC-co-MMA), were prepared by emulsifier-free emulsion copolymerization of methyl methacrylate (MMA) and MAPC using potassium peroxodisulfate (KPS) or 2,2′-azobis[2-(imidazolin-2-yl)propane] dihydrochloride (ABIP) as initiators. The ζ-potentials of the particles are –72 to –26 mV and 0 to 27 mV for poly(MAPC-co-MMA) produced by KPS and ABIP, respectively. Poly(MAPC-co-MMA) suppresses the adsorption of albumin, γ-globulin, and fibrinogen more than poly(MMA) as the control. From XPS measurements the MAPC moiety and the fragments of the initiator are located on the surface of the polymer films prepared from poly(MAPC-co-MMA). Egg yolk lecithin adsorbs on the surface of the films, and an organized adsorption layer of lipid, i. e., a hydrogel layer with an analogous structure to biomembrane, is formed. |
| Databáze: | OpenAIRE |
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