Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate
| Autor: | Teruo Kirikae, Motoki Inoue, Takashi Hamahata, Keiji Funatogawa, Masahiro Okada, Temmei Ito, Yumi Shimomura, Tetsushi Taguchi, Miwa Masuda, Tsutomu Furuzono, Yasumichi Kogai |
|---|---|
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 29:284-297 |
| ISSN: | 1530-8030 0883-9115 |
| DOI: | 10.1177/0883911514528409 |
| Popis: | A new material was prepared to reduce catheter infection composed of a flocked silicone sheet (AmTiO2NP-F) with TiO2 nanoparticle–immobilized poly(ethylene terephthalate) fibers modified with surface amino groups. This system was used in conjunction with a tissue adhesive composed of disuccinimidyl tartrate and human serum albumin. At a fixed disuccinimidyl tartrate content of 0.2 mmol in human serum albumin solution, AmTiO2NP-F bonded well with collagen-based casing (a model material for skin), with bond strength increasing to a maximum of 38 w/v% human serum albumin. The adhesive bonded AmTiO2NP-F to subcutaneous tissue in mice, and infiltration of the tissue into the AmTiO2NP-F further increased the bond strength for long-term insertions. The material was degraded within 7 days of implantation, and tissue reaction was mild, while infection was completely prevented. These results indicate that the combined use of AmTiO2NP-F and disuccinimidyl tartrate-A for implanted catheters can significantly alleviate the associated risk of infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|