Extracorporeal Life Support for Acute Respiratory Failure. A Systematic Review and Metaanalysis
| Autor: | Teagan Telesnicki, Laveena Munshi, Allan J. Walkey, Eddy Fan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Mechanical ventilation medicine.medical_specialty business.industry medicine.medical_treatment MEDLINE Intensive care unit Extracorporeal law.invention Randomized controlled trial law Life support medicine Observational study business Intensive care medicine Adverse effect |
| Zdroj: | Annals of the American Thoracic Society. 11:802-810 |
| ISSN: | 2325-6621 2329-6933 |
| Popis: | Rationale: Extracorporeal life support (ECLS) for acute respiratory failure has increased as a result of technological advancements and promising results from recent studies as compared with historical trials.Objectives: Systematically review the effect of ECLS compared with mechanical ventilation on mortality, length of stay, and adverse events in respiratory failure.Methods: Data sources included were MEDLINE, EMBASE, and CENTRAL (through to October 2013). Any randomized controlled trial (RCT) or observational study comparing ECLS to mechanical ventilation in adults was used. Two authors independently abstracted the data. Our primary outcome was mortality. Secondary outcomes included intensive care unit length of stay, hospital length of stay, and adverse events. A sensitivity analysis was performed restricted to RCTs and quasi-RCTs, and a number of predefined subgroups were identified to explore heterogeneity.Measurements and Main Results: Ten studies (four RCTs, six observational studies, 1,248 patien... |
| Databáze: | OpenAIRE |
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