| Autor: |
Kurt Tiesenhausen, Martin N. Vicenzi, Wolfgang Toller, Helfried Metzler, Peter Rehak, Robert Maier, Elisabeth Mahla, Norbert Watzinger, Anneliese Baumann |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Anesthesiology. 106:1088-1095 |
| ISSN: |
0003-3022 |
| Popis: |
Background Preoperative N-terminal pro-BNP (NT-proBNP) is independently associated with adverse cardiac outcome but does not anticipate the dynamic consequences of anesthesia and surgery. The authors hypothesized that a single postoperative NT-proBNP level provides additional prognostic information for in-hospital and late cardiac events. Methods Two hundred eighteen patients scheduled to undergo vascular surgery were enrolled and followed up for 24-30 months. Logistic regression and Cox proportional hazards model were performed to evaluate predictors of in-hospital and long-term cardiac outcome. The optimal discriminatory level of preoperative and postoperative NT-proBNP was determined by receiver operating characteristic analysis. Results During a median follow-up of 826 days, 44 patients (20%) experienced 51 cardiac events. Perioperatively, median NT-proBNP increased from 215 to 557 pg/ml (interquartile range, 83/457 to 221/1178 pg/ml; P Conclusion A single postoperative NT-proBNP determination provides important additional prognostic information to preoperative levels and may support therapeutic decisions to prevent subsequent structural myocardial damage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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