Sonographic detection of central nervous system defects in the first trimester of pregnancy
| Autor: | T. Van Mieghem, B. De Keersmaecker, Alexander Engels, Jan Deprest, Luc Joyeux, L. De Catte, David Baud, C. Brantner |
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| Rok vydání: | 2016 |
| Předmět: |
Pregnancy
medicine.medical_specialty Fetus Acrania 030219 obstetrics & reproductive medicine Spina bifida business.industry Obstetrics Central nervous system food and beverages Obstetrics and Gynecology medicine.disease nervous system diseases 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Gestation Stage (cooking) Agenesis of the corpus callosum business Genetics (clinical) |
| Zdroj: | Prenatal Diagnosis. 36:266-273 |
| ISSN: | 0197-3851 |
| Popis: | The fetal central nervous system can already be examined in the first trimester of pregnancy. Acrania, alobar holoprosencephaly, cephaloceles, and spina bifida can confidently be diagnosed at that stage and should actively be looked for in every fetus undergoing first-trimester ultrasound. For some other conditions, such as vermian anomalies and agenesis of the corpus callosum, markers have been identified, but the diagnosis can only be confirmed in the second trimester of gestation. For these conditions, data on sensitivity and more importantly specificity and false positives are lacking, and one should therefore be aware not to falsely reassure or scare expecting parents based on first-trimester findings. This review summarizes the current knowledge of first-trimester neurosonography in the normal and abnormal fetus and gives an overview of which diseases can be diagnosed. |
| Databáze: | OpenAIRE |
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