Cognitive outcomes of the bipolar depression electrical treatment trial (BETTER): a randomized, double-blind, sham-controlled study

Autor: Paulo A. Lotufo, Stephan Goerigk, Wagner F. Gattaz, Gabriel Tortella, Adriano Fernandes da Silva, Isabela M. Benseñor, Bernardo Sampaio-Junior, Lucas Borrione, Marina Moreno, Beny Lafer, Andre R. Brunoni, Adriano H. Moffa, Rodrigo Machado-Vieira
Rok vydání: 2020
Předmět:
Zdroj: European Archives of Psychiatry and Clinical Neuroscience. 271:93-100
ISSN: 1433-8491
0940-1334
0215-2878
DOI: 10.1007/s00406-020-01121-2
Popis: Bipolar depression is associated with marked cognitive deficits. Pharmacological treatments for this condition are limited and may aggravate depressive and cognitive symptoms. Therefore, therapeutic interventions that preserve adequate cognitive functioning are necessary. Our previous results demonstrated significant clinical efficacy of transcranial direct current stimulation (tDCS) in the Bipolar Depression Electrical Treatment Trial (BETTER). Here, cognitive outcomes of this study are reported. We randomized 59 patients with bipolar disorder I or II in an acute depressive episode to receive active (12 2 mA, 30-min, anodal-left, cathodal-right prefrontal cortex tDCS sessions) or sham tDCS. Patients were on stable pharmacological regimen for at least 2 weeks. A battery of 12 neuropsychological assessments in five cognitive domains (attention and processing speed, memory, language, inhibitory control, and working memory and executive function) was performed at baseline, after two weeks and at endpoint (week 6). No significant differences between groups over 6 weeks of treatment were observed for any cognitive outcomes. Moreover, no decrease in cognitive performance was observed. Our findings warrant further replication in larger studies. Trial Registration: clinicaltrials.gov Identifier: NCT02152878
Databáze: OpenAIRE
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