Prevalence and determinants of antibodies to hepatitis C virus and markers for hepatitis B virus infection in patients with HIV infection in Aquitaine
| Autor: | P Rispal, Ph. Morlat, P Trimoulet, H Fleury, P. Couzigou, JL Pellegrin, Dabis F, J.M. Ragnaud, E Monlun, Denis Lacoste, F Saillour, M. Dupon |
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| Rok vydání: | 1996 |
| Předmět: |
Hepatitis B virus
biology business.industry Hepatitis C virus General Engineering General Medicine Hepatitis C Hepatitis B medicine.disease_cause medicine.disease Virology Serology Acquired immunodeficiency syndrome (AIDS) Antigen Immunology medicine biology.protein General Earth and Planetary Sciences Antibody business General Environmental Science |
| Zdroj: | BMJ. 313:461-464 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.313.7055.461 |
| Popis: | Objective: To evaluate the prevalence of antibodies to hepatitis C virus and serological markers for hepatitis B virus infection in patients with HIV. Design: Cross sectional survey. Setting: Aquitaine, southwestern France, 1991-94. Subjects: 1935 HIV positive patients seen at least once since June 1991. Main outcome measures: Presence of antibodies to hepatitis C virus were detected by second or third generation enzyme linked immunosorbent assay (ELISA) and recombinant immunoblot assay (RIBA) and markers for hepatitis B virus detected by ELISA. Results: The prevalence was 42.5% (823) for antibodies to hepatitis C virus, 56.4 (507) for antibodies to hepatitis B core antigen, 6.9% (133) for hepatitis B surface antigen, 30.2% (584) for antibodies to hepatitis B core and surface antigen with no detectable surface antigen, 26.2% (507) for antibodies to core antigen only, and 4.8% (92) for antibodies to surface antigen only. The prevalence of antibodies to hepatitis C virus was 86.1% (726/843) in subjects who had bloodborne HIV infection and 7.3% (66/899) in those with sexually acquired infection. The prevalence of markers for hepatitis B was higher among homosexuals than in the other groups of patients, except for antibodies to surface antigen alone. The relation between markers for hepatitis B and hepatitis C virus was negative among men but positive among women. Conclusions: The results favour the hypothesis that hepatitis C virus is sexually transmitted much less commonly than either HIV or hepatitis B virus. |
| Databáze: | OpenAIRE |
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