Novel methods for synthesizing 2-chloroaldehyde from carbonyl compounds and converting it into 2-hydroxyaldehyde derivatives

Autor:	Shoji Akai, Ken-ichi Sato, Takao Sekiguchi
Rok vydání:	2001
Předmět:	chemistry.chemical_compound chemistry Sulfonium Organic Chemistry Drug Discovery Organic chemistry Biochemistry Trifluoromethanesulfonate
Zdroj:	Tetrahedron Letters. 42:3625-3628
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)00522-6
Popis:	2-Chloroaldehyde derivatives were synthesized from carbonyl compounds with [chloromethyl (dimethyl)sulfonium trifluoromethanesulfonate, ( 1 )] and DBU in THF in good yields. Further, 2-chloroaldehyde derivatives were converted into the corresponding 2-hydroxyaldehydes by treating the derivatives with n -Bu 4 NOH in good yields with the inverted configuration. The stereochemistry of all the products were determined by NMR (NOE).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::90c6a7662aea6936e3d745e244ada053 https://doi.org/10.1016/s0040-4039(01)00522-6 Zobrazit plný text záznamu Full Text from ScienceDirect