A New Xanthone and Anti-Inflammatory Constituents of Garcinia subelliptica
| Autor: | Jih Jung Chen, Hsiang Ruei Liao, Yun-Ping Lim, Lin Yang Cheng, Ping-Jyun Sung, Yueh-Hsiung Kuo, Chih-Wen Shu, Ming Chi Hung, Wen Lung Kuo, Sin Ling Wang, Jui Jen Wu |
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| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Chemistry medicine.drug_class Stereochemistry Superoxide Plant Science General Chemistry Garcinia subelliptica 01 natural sciences General Biochemistry Genetics and Molecular Biology Anti-inflammatory 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Xanthone medicine Ic50 values |
| Zdroj: | Chemistry of Natural Compounds. 53:649-652 |
| ISSN: | 1573-8388 0009-3130 |
| DOI: | 10.1007/s10600-017-2082-4 |
| Popis: | A new xanthone, garcisubellone (1), has been isolated from the roots of Garcinia subelliptica, together with three known compounds, subelliptenone E (2), 1,5-dihydroxy-3-methoxyxanthone (3), and 1,4,5-trihydroxyxanthone (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Garcisubellone (1) and 1,4,5-trihydroxyxanthone (4) exhibited potent inhibition, with IC50 values of 18.3 ± 2.2 and 15.6 ± 2.8 μM, respectively, against formyl-L-methionyl-L-leucyl-Lphenylalanine (fMLP)-induced superoxide anion (O2·–) generation. |
| Databáze: | OpenAIRE |
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