Immunohistochemical Localization of Versican, Link Protein and Hyaluronic Acid Binding Protein in the Human Periodontal Ligament

Autor:	Tadahiko Utsunomiya, Rei Sato, Kazutaka Kasai, Aki Otsuka, Masaru Yamaguchi, Kayo Kuyama, Hirotsugu Yamamoto
Rok vydání:	2014
Předmět:	Pathology medicine.medical_specialty biology Link protein Chemistry chemistry.chemical_compound stomatognathic system Proteoglycan Biotinylation Hyaluronic acid biology.protein medicine Versican Hyaluronic Acid Binding Protein Immunohistochemistry Periodontal fiber
Zdroj:	Open Journal of Stomatology. :446-451
ISSN:	2160-8717 2160-8709
DOI:	10.4236/ojst.2014.49060
Popis:	The purpose of the present study was to histopathologically and immunohistochemically investigate the distribution of proteoglycans in human periodontal ligament (PDL). Specimens from osteotomy and tooth extraction having healthy PDL were studied. Histologically, PDL consisted of fibrous tissues, involving a compact arrangement area and edematous or myxoid area. Immuno-histochemically, versican binding region (12C5), versican link protein (8A4) and biotinylated hyaluronic acid binding protein (B-HABP) were distributed in PDL. In addition, positive immunore-activity for 12C5 and 8A4 was stronger in the compact arrangement area than in the edematous or myxoid area. Reactivity for B-HABP was stronger in the edematous or myxoid area than in the compact fibrous area. These results suggest that versican and link protein are associated with fibrous tissues, whereas hyaluronic acid is related to the formation of edematous and/or myxoid tissue in human PDL. These substances may play a role in periodontal homeostasis by protecting against mechanical stress.
Databáze:	OpenAIRE
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