CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: a case report

Autor:	Hyeona Bae, Do-Hyeon Yu, Sang-Ki Kim, Jihu Kim, Dongbin Lee, Jinho Park, Yu jin Lim, Sun Woo Shin, Dong-In Jung, ARom Cho
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty biology business.industry CD3 CD34 medicine.disease CD79A Lymphoma Immunophenotyping hemic and lymphatic diseases medicine biology.protein CD5 business CD8 Generalized lymphadenopathy
Zdroj:	Korean Journal of Veterinary Research. 61:e21
ISSN:	2466-1392 2466-1384
DOI:	10.14405/kjvr.2021.61.e21
Popis:	Canine T-zone lymphoma (TZL) is a mature T-cell lymphoma in dogs. The diagnosis and sub-classification are impossible without biopsy or immunophenotyping by flow cytometry. An 11-year-old, spayed, female Golden Retriever presented with lymph node enlargement. Clinical examination was consistent with canine multicentric lymphoma. However, immunophenotyping revealed positive for CD3, CD4, CD5, CD8, CD21, TCRαβ, and MHCII but negative for CD34, CD45, CD79a, and TCRγδ. Histopathology revealed lymphocytes expanding to the cortex-preserving architecture and thinning of the nodal capsule, and CD3 positive but PAX-5 negative. Owing to the indolent nature of TZL, careful monitoring approach without clinical intervention was utilized.
Databáze:	OpenAIRE
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