Prognostic molecular markers in head and neck squamous cell carcinoma in a New Zealand population: matrix metalloproteinase-2 and sialyl Lewis x antigen

Autor: R. Theo Gregor, Michael Arendse, Michael B. Jameson, Lindsay D. Plank, Indunil Gunawardena
Rok vydání: 2013
Předmět:
Zdroj: ANZ Journal of Surgery. 85:843-848
ISSN: 1445-1433
DOI: 10.1111/ans.12424
Popis: Objective: The survival rate for head and neck squamous cell carcinoma (HNSCC) is among the lowest of the major cancers and has not substantially improved in the past two decades. Tumours with similar histological features may have widely differing clinical outcomes and thus identification of prognostic and predictive biomarkers may be valuable for determining appropriate clinical management strategies. The objective of this study was to establish the prognostic significance of six molecular markers in HNSCC in a New Zealand population: matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), tissue inhibitor of matrix metalloproteinase-1, sialyl Lewis antigens a and x (sLe a , sLe x ) and alpha B-crystallin. Methods: Retrospective review of 145 sequential HNSCC patients from a tertiary centre with minimum 3 years surveillance. Sections from formalin-fixed paraffinembedded tumour blocks were immunostained for the molecular markers and scored. Cox regression modelling was used to adjust for potential confounding variables impacting on cancer survival. Results: Multivariate analysis for individual biomarkers, controlling for age, sex, tumour grade, N-stage, T-stage, tumour site, smoking history and alcohol use, revealed poorer survival with tumour expression of MMP-2 (hazard ratio = 1.98, 95% confidence interval: 1.11‐3.52, P = 0.021) and sLe x (hazard ratio = 3.22, 95% confidence interval: 1.33‐7.80, P = 0.010). A stepwise analysis showed that MMP-2 and sLe x
Databáze: OpenAIRE
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