Nerolidol-loaded nanospheres prevent behavioral impairment via ameliorating Na+, K+-ATPase and AChE activities as well as reducing oxidative stress in the brain of Trypanosoma evansi-infected mice
| Autor: | Carine F. Souza, Lenita M. Stefani, Karen L.S. Moreira, Silvia Gonzalez Monteiro, Thirssa H. Grando, Marcelo L. da Veiga, Maria Izabel U.M. da Rocha, Luciana F. Cossetin, Andressa S. Schafer, Aleksandro S. Da Silva, Matheus D. Baldissera, Ana P.T. da Silva |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.disease_cause Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine TBARS Na+/K+-ATPase Pharmacology chemistry.chemical_classification Reactive oxygen species biology General Medicine Trypanosoma evansi biology.organism_classification Acetylcholinesterase 030104 developmental biology Endocrinology chemistry Biochemistry Catalase biology.protein 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 390:139-148 |
| ISSN: | 1432-1912 0028-1298 |
| Popis: | The aim of this study was to investigate the effect of nerolidol-loaded nanospheres (N-NS) on the treatment of memory impairment caused by Trypanosoma evansi in mice, as well as oxidative stress, and Na+, K+-ATPase and acetylcholinesterase (AChE) activities in brain tissue. Animals were submitted to behavioral tasks (inhibitory avoidance task and open-field test) 4 days postinfection (PI). Reactive oxygen species (ROS) and thiobarbituric acid-reactive substance (TBARS) levels and catalase (CAT), superoxide dismutase (SOD), Na+, K+-ATPase and AChE activities were measured on the fifth-day PI. T. evansi-infected mice showed memory deficit, increased ROS and TBARS levels and SOD and AChE activities, and decreased CAT and Na+, K+-ATPase activities compared to uninfected mice. N-NS prevented memory impairment and oxidative stress parameters (except SOD activity), while free nerolidol (N-F) restored only CAT activity. Also, N-NS treatment was able to prevent alterations in Na+, K+-ATPase and AChE activities caused by T. evansi infection. A significantly negative correlation was observed between memory and ROS production (p |
| Databáze: | OpenAIRE |
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