Fragments of Cell-Free DNA (cfDNA) Enhance Transcription Activity in Human Mesenchymal Stem Cells (hMSCs) and Inhibit Their In Vitro Differentiation

Autor:	Anna Yu. Alekseeva, Larisa V. Kameneva, Elena M. Malinovskaya, Svetlana V. Kostyuk, T. D. Smirnova, Marina S. Konkova, Liudmila V. Efremova, Liudmila Lyubchenko, A. V. Ermakov, Natalya N. Veiko
Rok vydání:	2010
Předmět:	Cell-free fetal DNA Transcription (biology) Apoptosis medicine.medical_treatment Mesenchymal stem cell medicine TLR9 Stem-cell therapy Signal transduction Biology In vitro Cell biology
Zdroj:	Circulating Nucleic Acids in Plasma and Serum ISBN: 9789048193813
DOI:	10.1007/978-90-481-9382-0_27
Popis:	CpG-enriched rDNA accumulating in human cfDNA significantly stimulate gene transcription in mesenchymal stem cells by activating TLR9 and MyD88-dependent signaling pathways and inhibiting differentiation of mesenchymal stem cells into adipocytes. These data are important for stem cell therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::90b0b01c4324c1f50495cf79d5366f92 https://doi.org/10.1007/978-90-481-9382-0_27 Zobrazit plný text záznamu