Simple, Rapid Procedure for the Synthesis of Chloromethyl Methyl Ether and Other Chloro Alkyl Ethers1

Autor:	Katherine Belecki, Martin A. Berliner
Rok vydání:	2005
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Yield (chemistry) Organic Chemistry Organic chemistry chemistry.chemical_element Halide Ether Zinc Chloromethyl methyl ether Alkyl Catalysis
Zdroj:	The Journal of Organic Chemistry. 70:9618-9621
ISSN:	1520-6904 0022-3263
Popis:	Zinc(II) salts catalyze the reaction between acetals and acid halides to provide haloalkyl ethers in near-quantitative yield. Reactions from millimole to mole scale are typically complete in 1−4 h with 0.01 mol % catalyst. The solutions of haloalkyl ethers thus obtained can be utilized directly in reactions in which the presence of the ester byproduct does not interfere. Excess haloalkyl ether is destroyed on workup, thereby minimizing exposure to this class of carcinogenic compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::90afbad1ba4a81a86b83fd1377e64250 https://doi.org/10.1021/jo051344g Zobrazit plný text záznamu