Sorption of 223Ra and 211Pb on modified nanodiamonds for potential application in radiotherapy
| Autor: | N. E. Borisova, N. N. Dogadkin, B. L. Garashchenko, Ruslan Yu. Yakovlev |
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| Rok vydání: | 2018 |
| Předmět: |
Aqueous solution
Chemistry Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Nanoparticle Sorption 02 engineering and technology 021001 nanoscience & nanotechnology 010403 inorganic & nuclear chemistry Grafting 01 natural sciences Pollution 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound Adsorption Nuclear Energy and Engineering Yield (chemistry) Desorption Radiology Nuclear Medicine and imaging 0210 nano-technology Spectroscopy Nuclear chemistry Carbodiimide |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 318:2415-2423 |
| ISSN: | 1588-2780 0236-5731 |
| Popis: | 223Ra and 211Pb/211Bi radionuclides with radiochemical purity were obtained from 227Ac/223Ra generator on DGA resin. Covalent grafting of organic complexons (ethylenediaminetetraacetic acid—EDTA and derivatives of amino acids—L1 and L2 to aminated nanodiamonds (ND) was performed by carbodiimide method. Adsorption behavior of Ra and Pb in plasma volume expander on modified nanodiamonds was studied in detail. Effective adsorption have been found for 211Pb in physiologically acceptable conditions. Sorption behavior of generator radionuclides 223Ra and 211Pb on the surface of ND-L1 and ND-L2 in aqueous solution (pH = 6.3) was studied. It was shown that the labeling yield of 211Pb from the solution was about 94%. The sorption of 223Ra under the same conditions was weak. The sorption/desorption kinetics of 211Pb on the surface of ND-EDTA in the plasma volume expander was studied. The desorption rate of 211Pb did not exceed 2.5% within 60 min (pH 7.2–7.4). |
| Databáze: | OpenAIRE |
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