Electrospun poly(l-lactic acid) fiber mats containing crude Garcinia mangostana extracts for use as wound dressings

Autor: Porntipa Pankongadisak, Pitt Supaphol, Orawan Suwantong, Suwanna Deachathai
Rok vydání: 2014
Předmět:
Zdroj: Polymer Bulletin. 71:925-949
ISSN: 1436-2449
0170-0839
DOI: 10.1007/s00289-014-1102-9
Popis: Poly(l-lactic acid) (PLLA) fiber mats containing two types of crude Garcinia mangostana Linn. (GM) extract [i.e., dichloromethane extract (dGM) and acetone extract (aGM)] were successfully prepared by electrospinning process. Both the neat and the GM-loaded PLLA fibers were smooth, with the average diameters ranging between 0.77 and 1.14 μm. The release characteristics of GM from the GM-loaded PLLA fiber mats were carried out by total immersion method in acetate buffer or simulated body fluid that contained 0.5 % v/v Tween 80 and 3 % v/v methanol (hereafter, A/T/M or S/T/M medium) at either 32 or 37 °C, respectively. The maximum cumulative amounts of GM released from the GM-loaded PLLA fiber mats in the S/T/M medium were greater than those in the A/T/M medium. Moreover, the cumulative amounts of GM released from the aGM-loaded PLLA fiber mats were greater than those from the dGM-loaded PLLA fiber mats in both types of medium. The antibacterial activity of the dGM-loaded PLLA fiber mats was greatest against Staphylococcus aureus DMST 20654, while that of the aGM-loaded PLLA fiber mats was greatest against S. aureus ATCC 25923 and S. epidermidis. Lastly, only the dGM-loaded PLLA fiber mats at extraction ratio of 10 mg mL−1 were toxic to the human dermal fibroblasts.
Databáze: OpenAIRE
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