Hemodynamic, electrocardiographic, and cellular effects of diltiazem treatment after cardiac arrest and resuscitation

Autor: Robert A. Niskanen, Michael J. Emery, W. Douglas Weaver, Robert D. Swenson, Dennis D. Reichenbach, Christopher L. Fellows
Rok vydání: 1989
Předmět:
Zdroj: Journal of Critical Care. 4:166-175
ISSN: 0883-9441
Popis: Thirty-one large dogs were treated with diltiazem or placebo after a 15-minute period of cardiac arrest and cardiopulmonary resuscitation to examine the influence of diltiazem treatment on the resulting ECG rhythm, hemodynamics, and extent of myocardial and cerebral injury after cardiac resuscitation. Diltiazem had no adverse effects on resuscitation or the rhythm and blood pressure immediately after defibrillation. There were no differences in the total number of shocks required to obtain pulse, the type of rhythm achieved, the occurrence of heart block, or resuscitation rates between treatment groups. By 30 minutes after resuscitation, cardiac output was higher in the dogs that received diltiazem: 4.1 ± 1.4 L/min at one hour in the diltiazem group v 2.4 ± 1.5 L/min in the placebo group (P
Databáze: OpenAIRE