Influence of Solution Acidity on Structure of Actinocin Derivatives and Their Affinity to DNA Studied as a Function of pH by Raman Spectroscopy

Autor:	Ju. N. Bliznyuk, T. V. Bolbukh, D. V. Ovchinnikov, E. B. Kruglova
Rok vydání:	2009
Předmět:	Stereochemistry Molecular biophysics Protonation Atomic and Molecular Physics and Optics Analytical Chemistry chemistry.chemical_compound Crystallography symbols.namesake chemistry Ionic strength Amide Side chain symbols Titration Methylene Raman spectroscopy Spectroscopy
Zdroj:	Spectroscopy Letters. 42:498-505
ISSN:	1532-2289 0038-7010
DOI:	10.1080/00387010903022285
Popis:	An important problem of molecular biophysics is the influence of pH and ionic strength of a solution on chemical structures and charge of biologically active substances. By means of pH titration and Raman spectroscopy methods, the influence of solution acidity on structural changes of actinocin derivatives was investigated, analogues to antitumor antibiotic actinomycin D. It has been shown that these ligands have different values of cation charges in neutral solutions. From analysis of Raman spectra, it was concluded that protonation of nitrogen atom and amino group of the phenoxazone ring starts only at pH
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::909a1bfeddd6a9a601b64d41405f3aa7 https://doi.org/10.1080/00387010903022285 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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