4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp
| Autor: | Inho Yang, Dongyup Hahn, Jisoo Yoon, Sang Jip Nam, Dayoung Kim, William Fenical |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Circular dichroism
biology 010405 organic chemistry Stereochemistry Organic Chemistry Crystallographic data biology.organism_classification 01 natural sciences Biochemistry Streptomyces 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Drug Discovery Spectral data Pikromycin Bacteria |
| Zdroj: | Tetrahedron Letters. 58:2322-2324 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.03.088 |
| Popis: | HPLC–UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data. |
| Databáze: | OpenAIRE |
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