Metal-Free Synthesis of Oxazinones and Their Reductive Ring Opening to Provide Cyclopropyl Carbinols

Autor:	Alexander J. Craig, Bill C. Hawkins
Rok vydání:	2017
Předmět:	Metal free 010405 organic chemistry Chemistry Yield (chemistry) Organic Chemistry Organic chemistry Structural diversity Amine gas treating 010402 general chemistry Ring (chemistry) 01 natural sciences Catalysis 0104 chemical sciences
Zdroj:	Synthesis. 49:1955-1968
ISSN:	1437-210X 0039-7881
Popis:	General routes for the synthesis of 1,3-oxazin-4-ones are discussed, with particular attention paid to recent developments in the field. The syntheses of amine functionalised cyclopropyl carbinols via a hydride-mediated reduction of various 5-chloroethyl-1,3-oxazin-4-enones in moderate to good yield are disclosed. This new method provides an opportunity to access greater structural diversity within these useful synthetic building blocks.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::90966dc6c87b197ecd2a431290fc6828 https://doi.org/10.1055/s-0036-1588748 Zobrazit plný text záznamu