Enantioselective synthesis of a cyclobutane analogue of Milnacipran
| Autor: | David-Alexandre Buisson, Marc Nicolas, Dinh-Vu Nguyen, Edmond Gravel, Eric Doris |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Chemistry Stereochemistry Organic Chemistry Enantioselective synthesis Optically active 010402 general chemistry Ring (chemistry) 01 natural sciences 0104 chemical sciences Cyclobutane Cyclopropane Stereocenter chemistry.chemical_compound Milnacipran medicine Derivative (chemistry) medicine.drug |
| Zdroj: | Organic Chemistry Frontiers. 4:1276-1280 |
| ISSN: | 2052-4129 |
| DOI: | 10.1039/c7qo00140a |
| Popis: | The asymmetric synthesis of a cyclobutane analogue of the antidepressant drug Milnacipran is reported. The optically active derivative incorporates a central cyclobutane ring in lieu of the cyclopropane unit classically found in Milnacipran. The two stereogenic centres borne by the cyclobutane were sequentially installed starting from phenylacetonitrile. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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