| Autor: |
Maicon Machado Sulzbacher, Lucas Machado Sulzbacher, Felipe Rafael Passos, Bruna Letícia Endl Bilibio, Kauana de Oliveira, Wellington Felipe Althaus, Matias Nunes Frizzo, Mirna Stela Ludwig, Ivana Beatrice Mânica Da Cruz, Thiago Gomes Heck |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.21203/rs.3.rs-64379/v1 |
| Popis: |
Objective The Murine Sepsis Score (MSS) is used to assess the severity of sepsis in rats and mice based on observational characteristics. The quantitative variables of blood glucose, body weight and temperature are predictors of severity in experimental models of sepsis. Therefore, our study sought to adapt the MSS with the same variables to indicate earlier the severity of the disease in murine models of the disease. Results Sepsis mice presented hypoglycemia, weight loss, and hypothermia. Therefore, these variables were included in the Adapted Murine Sepsis Score (A-MSS). The A-MASS presented 100% specificity and 87.5% sensibility been able to differentiate the early sepsis symptoms and its severity. The A-MSS allows an early and more complete diagnosis of sepsis in mice and might be considered as a procedure to improve the analysis of systemic sepsis dysfunction in murine experimental models. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
