Noncovalent fluorous interactions for the synthesis of carbohydrate microarrays

Autor:	Gisun Park, Kwang-Seuk Ko, Nicola L. B. Pohl, Firoz A. Jaipuri, Sreeman K. Mamidyala
Rok vydání:	2006
Předmět:	Arabinose chemistry.chemical_classification Rhamnose Organic Chemistry Maltose Carbohydrate Biochemistry Arachis hypogaea Inorganic Chemistry chemistry.chemical_compound chemistry Glucosamine Environmental Chemistry Non-covalent interactions Physical and Theoretical Chemistry DNA microarray
Zdroj:	Journal of Fluorine Chemistry. 127:571-579
ISSN:	0022-1139
DOI:	10.1016/j.jfluchem.2006.01.001
Popis:	A surface patterning method based on noncovalent immobilization of fluorous-tagged sugars on fluorous-derivatized glass slides allows the facile fabrication of carbohydrate microarrays. To expand the scope of these arrays, the first syntheses are reported of arabinose, rhamnose, lactose, maltose, and glucosamine tagged with a single C8F17-tail for ease of purification as well as array formation. Screening of these carbohydrate microarrays against lectins from Triticum vulgaris (WGA) and Arachis hypogaea (PNA) demonstrate that the noncovalent fluorous–fluorous interaction is sufficient to retain not only mono- but also disaccharides under the biological assay conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9075f5659af19cb6ec6873739f5840f5 https://doi.org/10.1016/j.jfluchem.2006.01.001 Zobrazit plný text záznamu Full Text from ScienceDirect