The ameliorative effect of the solvent extracts of Ocimum basilicum against acetaminophen-induced liver damage in albino rats

Autor: Mathew. O. Abatan, Adekunle Babajide Rowaiye, Benjamin. O. Ocheja, Olatunde. B. Akanbi, G. Ada, Oluwatosin. O. Baba-Onoja, Titilayo. M. Asala, Suliat. A. Salami
Rok vydání: 2021
Předmět:
Zdroj: Journal of Phytomedicine and Therapeutics. 20
ISSN: 1118-1028
DOI: 10.4314/jopat.v20i1.4
Popis: This study was designed to evaluate the protective activities of 4 different Ocimum basilicum L whole plant extracts against acute acetaminophen-induced liver damage in albino rats. A total of 42 rats were divided into 7 groups comprising the control (acetaminophen, water, and silymarin treated) groups and OB-treated (chloroform, diethylether, ethylacetate, and methanol extract) groups. Each treatment group was made up of 6 rats, with 3 replicates of 2 rats each. At the end of the treatment period, blood samples were collected to investigate the activities of liver enzymes, and liver tissue was harvested for histological analysis. Rats pre-treated with OB extracts showed decreased (p
Databáze: OpenAIRE