Activation of the aryl hydrocarbon receptor in vivo primes human T cells for interleukin 22 production and inhibits Th17 cells
| Autor: | Nicolò Costantino Brembilla, Matthes T, J-M Ramirez, Jm Dayer, J-H Saurat, Carlo Chizzolini, E. Roosnek, R Chicheportiche, Olivier Sorg |
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| Rok vydání: | 2010 |
| Předmět: |
Aryl hydrocarbon receptor nuclear translocator
biology Ligand business.industry T cell Cellular differentiation Immunology respiratory system Aryl hydrocarbon receptor General Biochemistry Genetics and Molecular Biology respiratory tract diseases Cell biology Interleukin 22 medicine.anatomical_structure Rheumatology In vivo biology.protein medicine Immunology and Allergy business Transcription factor |
| Zdroj: | Annals of the Rheumatic Diseases. 69:A74-A74 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2010.129668y |
| Popis: | Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating dioxin effects, favour Th17 cell differentiation and exacerbate autoimmunity in mice. The authors investigated how AHR ligands affect human T cell polarisation. The high affinity and stable AHR ligand dioxin as well as the natural AHR ligand … |
| Databáze: | OpenAIRE |
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