Acquired von Willebrand syndrome as side effect of valproic acid therapy in children is rare

Autor:	U. Budde, Wolfgang Eberl, H-J Christen, R Knapp, A. Mey, K Bentele, Reinhard Schneppenheim
Rok vydání:	2009
Předmět:	medicine.medical_specialty Valproic Acid Side effect biology business.industry Hematology Fibrinogen Endocrinology Acquired von Willebrand syndrome Von Willebrand factor Coagulation Internal medicine medicine biology.protein Clinical significance Platelet business medicine.drug
Zdroj:	Hämostaseologie. 29:137-142
ISSN:	2567-5761 0720-9355
DOI:	10.1055/s-0037-1617026
Popis:	SummaryTo determine the frequency and clinical relevance of acquired von Willebrand syndrome (aVWS) due to antiepileptic therapy by valproic acid, we investigated 50 consecutive children in three neuropediatric institutions. Coagulation factors were determined in local laboratories before and three times after starting therapy with valproic acid. Parameters of von Willebrand factor (VWF) were additionally investigated in a reference laboratory including multimeric analysis. Significant changes in the coagulation system were found concerning fibrinogen (decreased from 287 ± 70 mg/dl to 222 ± 67 mg/dl; p < 0.001) and platelet count. Changes of VWF para -meters were also found but no patient developed laboratory defined aVWS. We conclude that the bleeding tendency observed in some children undergoing antiepileptic therapy with valproic acid is not due to aVWS.
Databáze:	OpenAIRE
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