Studies of Cerebral Protective Agents. Preparation and Pharmacological Evaluation of 1-(1,4-Benzoquinon-2-yl)-1,2,3,4-tetrahydronaphthalenes as Potent Cerebral Protective Agents

Autor:	Toshio Tatsuoka, Tomochika Ohno, Kenji Suzuki, K. Aisaka, Fumio Satoh, Seiji Miyano, Takafumi Ishihara, Kunihiro Sumoto, Ryoko Ogino, Manami Kuroki
Rok vydání:	1996
Předmět:	Antioxidant Chemistry medicine.drug_class medicine.medical_treatment Carboxamide General Chemistry General Medicine Pharmacology Hypoxia (medical) Chemical synthesis In vitro Biochemistry In vivo Oral administration Protective Agents Drug Discovery medicine medicine.symptom
Zdroj:	Chemical and Pharmaceutical Bulletin. 44:132-138
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.44.132
Popis:	Two new series of 1-(1, 4-benzoquinon-2-yl)-1, 2, 3, 4-tetrahydronaphthalenes (3, 4) were synthesized for evaluation of their pharmacological activities. These compounds showed significant anti-lipid peroxidation (ALP) activities with rat brain homogenate and some of them possessed a protective effect against hypobaric hypoxia in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9053ec5c19265d60bddf51d009236980 https://doi.org/10.1248/cpb.44.132 Zobrazit plný text záznamu