| Autor: | Ingolf E. Blasig, Eberhard Nissen, Gerd Wallukat, Csaba Csonka, Svenia Podlowski, Rosemarie Morwinski, Arpad Tosaki |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
biology business.industry Clinical Biochemistry Autoantibody Cardiomyopathy Adrenergic Dilated cardiomyopathy Cell Biology General Medicine medicine.disease Epitope Endocrinology Internal medicine Extracellular medicine biology.protein Antibody Signal transduction business Molecular Biology |
| Zdroj: | Molecular and Cellular Biochemistry. 251:67-75 |
| ISSN: | 0300-8177 |
| Popis: | Eighteen month old spontaneously hypertensive rats (SHR-rats) showed myocardial dysfunction and autoantibodies directed against the β1-adrenoceptor similarly as known in human dilated cardiomyopathy or Chagas' disease. The agonist-like antibodies were able to activate the β1-adrenoceptor mediated signal transduction cascade in cultured rat cardiomyocytes and induced a long-lasting stimulatory effect resulting in a harmful adrenergic overdrive. The antibodies recognized an epitope of the second extracellular loop of the β1-adrenoceptor identical to that epitope identified in Chagas' disease. In conclusion, our assumption is supported that old SHR-rat are an useful animal model for investigating the role of anti-β1-adrenoceptor antibodies in the induction of human cardiomyopathy. |
| Databáze: | OpenAIRE |
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