O36 The introduction of multi-drug resistant (MDR) Gram-negative bacilli (GNB) in Toronto, Canada

Autor:	P. Akhavan, S. Poutanen, N. Prayitno, Barbara M. Willey
Rok vydání:	2009
Předmět:	Microbiology (medical) medicine.medical_specialty business.industry General Medicine Gram negative bacilli Pharmacology Body weight Infectious Diseases Internal medicine medicine Multi drug resistant Positive relationship Pharmacology (medical) Dosing business
Zdroj:	International Journal of Antimicrobial Agents. 34:S13
ISSN:	0924-8579
Popis:	the slope of the regression line between corrected AUC0 24 and ABW was 0.0271. Conclusions: This study reveals that AUC0 24 acts independently of body weight, as our simulations were able to achieve the same AUC0 24 for each patient regardless weight. This is not the case for V, which demonstrated a positive relationship with weight. Unlike dosing based on V, AUC0 24 based dosing would eliminate the need to stratify patients based on weight as well as the need to choose an appropriate correction factor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9051675a67da4e2107598745c2ae7569 https://doi.org/10.1016/s0924-8579(09)70183-9 Zobrazit plný text záznamu Full Text from ScienceDirect