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S 21 ANNUAL CONFERENCE—2013 M isella n eo u s administered intraperitoneally to the animals (group-1) at the dose of 20 mg/kg at 24 h before tumor illumination, and administered intravenously at 5 mg/kg in group-2 animals. The cavity was then illuminated with a flat-cut fiber optic cable through a small incision and the peritoneum is filled with normal saline. Whole-peritoneum was irradiated using a 630-nm CW diode laser with a dose of 100 J/ cm2. The pathologic status was investigated 4 days later. Total tumor count was detected. Results: PDT in group A and B mice resulted in a significant lowered tumor weight and account of tumor nodes compared with the control group. Percentage of cancer necrosis in group A animal significantly higher than in group B and control group. Significant increases in TUNEL-positive cells and Ki-67-positive cells ware seen, indicating that PDT led to not only cell death but also inhibition of cancer proliferation. Conclusions: Preliminary results demonstrate feasibility of PDT for peritoneal carcinomatosis. The results show that PDT is effective for treatment of cholangiocarcinoma, and it will be a novel potential application of laparoscope. Corresponding author: Kai-Wen Huang. E-mail: skywing@ntuh.gov.tw EFFECT OF N ACETYLCYSTEINE (NAC) IN HYPOXIA INDUCED LIVER INJURY (HILI)– A RANDOMIZED PLACEBO CONTROL CLINICAL TRIAL P. Basu, K. Mittimanj, Niraj J. Shah, R. Siriki, K. Rahaman, Niraj Atluri, R. Jr Brown Columbia School of Physicians and Surgeons, Forest Hills Hospital, Hofstra North Shore-LIJ School of Medicine, Forest Hills Hospital, Hofstra North Shore-LIJ School of Medicine, James J Peters VA Medical Center, Mount Sinai School of Medicine, New York Objectives: HILI is common with a prevalence of 10% in US. Transient shift of intra hepatic hemodynamic compromise leads to tissue hypoxia and induces hypoxia induced protein (HIP), heat shock protein 70 (HSP24, 70), Endothelial reticular stress (ER) leading to reperfusion injury (RI). Dramatic rise of transaminases, drastic reversal with restoration of perfusion in weeks follows. In cirrhotics HILI requires liver transplantation. This study evaluated spontaneous recovery and salvage in HILI utilizing NAC. Methods: Sixty patients (n=60) with mean arterial pressure (MAP) A2 (57%) in day 3, in CLD NAC (A2)> placebo (A1) clinical recovery over placebo at 3rd day, (44%) over (36%) 6th day. Larger trial need to establish the routine usage of IV NAC in HILI. Corresponding author: Patrick Basu. E-mail: basu.patrick@gmail.com DIABETES: ITS IMPACT ON LIVER DISEASES Mrudul Vishanji Dharod Deepak Narayan Amarapurkar Bombay Hospital and Medical Research Centre, 12, Marine Lines |
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